Chronic fatigue studies
Conclusion: Fulvic and humic acids can enhance the biochemical generation of energy in the body.
Title: Effect of humic substances on mitochondrial respiration and oxidative phosphorylation.
Document Type: Peer-Reviewed Journal Article
Conclusion: Fulvic and humic acids extracted from a podzol were shown to stimulate respiration in rat liver mitochondria, when present at concentrations between 40 and 360 mg/L. Low molecular weight fractions induced a more significant increase in respiration than high molecular weight material. Humic substances, at concentrations between 40 and 400 mg/L, typically also increase the efficiency of the oxidative phosphorylation process in vitro, particularly after contact periods with mitochondria exceeding 1 hour.
Link: https://sci-hub.hkvisa.net/10.1016/0048-9697(87)90521-3
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Conclusion: Humic and fulvic acid supplements increase energy and reduce fatigue.
Title: Mechanisms of action of humic substances as growth promoters in animals
Document Type: Book Chapter
Conclusion: In humans, HA and FA preparations are promoted as supplements to increase energy and reduce fatigue. In a rodent model, a product containing 60–80% HS reversed negative behavioral symptoms of depression and anxiety caused by chronic fatigue syndrome and also stabilized the HPA axis stress response by reversing the drop in corticosterone levels and adrenal gland weight; the effects of HS were suggested to be due in part to regulation of mitochondrial bioenergetics by increasing the activities of NADH dehydrogenase, succinate dehydrogenase, cytochrome oxidase, and mitochondrial ATP synthase.
Link: https://www.intechopen.com/online-first/82760
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Conclusion: Herbal composition containing fulvic acid reduces fatigue.
Title: Anti-fatigue effect of OM-X, a plant extract fermented with lactic acid bacteria and bifidobacteria: a comparative, randomized, placebo-controlled, double-blind study
Document Type: Peer-Reviewed Journal Article
Conclusion: In conclusion, we found that 12 weeks of taking OM-X made from fermented plant extract with LAB and bifidobacteria could improve the feeling of fatigue in healthy people with temporary fatigue. Please note that the test food, OM-X, is made from fermented extract, which consists of various kinds of Japanese plants with 12 kinds of LAB and bifidobacteria such as TH10. The active ingredient includes fulvic acid, d-amino acids, l-amino acids, melanoidin, polyphenols, organic acids, fatty acids, vitamins, minerals, dietary fibers, oligosaccharides, LAB and bifidobacteria.
Link: https://www.sciencedirect.com/science/article/pii/S1756464622002985
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Conclusion: Shilajit reduces fatigue symptoms in chronic fatigue syndrome.
Title: Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats
Document Type: Peer-Reviewed Journal Article
Conclusion: The results indicate that shilajit mitigates the effects of CFS in this model, possibly by modulating the HPA axis and preserving mitochondrial function and integrity. The reversal of CFS-induced behavioral symptoms and mitochondrial bioenergetics by shilajit indicates that mitochondria are a potential target for the treatment of CFS.
Link: https://sci-hub.hkvisa.net/10.1016/j.jep.2012.06.002
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Conclusion: Shilajit helps reduce fatigue and tiredness.
Title: Shilajit: A Panacea for High Altitude Problems.
Document Type: Peer-Reviewed Journal Article
Conclusion: Shilajit actively participates in the transportation of nutrients to deep tissues and helps to overcome tiredness, lethargy and chronic fatigue.
Link: https://www.ncbi.nlm.nih.gov/pubmed/20532096
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Conclusion: Fulvic acid contained in shilajit increases energy production in humans.
Title: Energy and health benefits of Shilajit
Document Type: Book Chapter
Conclusion: Subjects received 200 mg of processed shilajit once daily for 15 days. Treatment with shilajit significantly increased energy production and exercise. Furthermore, energy production was confirmed based on increases in adenosine triphosphate (ATP), ATP/adenosine diphosphate (ADP) ratio, coenzyme Q10 (CoQ10), total adenine nucleotides, adenylate energy charge, and whole blood uric acid levels.
Link: https://sci-hub.ru/https://www.sciencedirect.com/science/article/pii/B9780128054130000120
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Conclusion: Fulvic acid contained in shilajit is known to improve endurance and strength in humans.
Title: Selected herbs and human exercise performance.
Document Type: Review Article
Bottom Line: Shilajit (or mummio), which contains fulvic acid, has anti-stress properties and improves endurance and strength. Eastern European weightlifters have been using mummio as part of an "herbal anabolic stack" to promote better strength, recovery, and muscle hypertrophy.
Link: https://sci-hub.ru/https://pubmed.ncbi.nlm.nih.gov/10919969/
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Conclusion: Shilajit containing fulvic acid helps to maintain muscle strength in humans.
Title: The effects of Shilajit supplementation on fatigue-induced decrease in muscle strength and serum hydroxyproline levels.
Document Type: Journal Article
Conclusion: The results of the present study demonstrated that 8 weeks of PrimaVie® Shilajit supplementation at 500 mg per day promoted retention of maximal muscle strength following fatigue protocol and decreased baseline serum hydroxyproline, an indirect biomarker of collagen degradation and connective tissue integrity following high-intensity exercise. Therefore, PrimaVie® Shilajit supplementation at 500 mg per day elicited favorable adaptations in muscle and connective tissue.
