Antifungal studies
Conclusion: Fulvic acid shows antifungal properties.
Title: Carbohydrate-derived fulvic acid: an in vitro investigation of a novel membrane-active antiseptic agent against Candida albicans biofilms
Document Type: Peer-Reviewed Journal Article
Conclusion: The aim of this study was to evaluate the antifungal activity of carbohydrate-derived fulvic acid (CHD-FA) against Candida albicans and to characterize its mode of action. CHD-FA was active against planktonic and sessile C. albicans at concentrations of 0.125 and 0.25% respectively, and was shown to be fungicidal, acting through disruption of cell membrane activity. Overall, based on the promising in vitro spectrum of activity and minimal biofilm resistance of the inexpensive natural antiseptic CHD-FA, further studies are required to determine its applicability for clinical use.
Link: https://www.frontiersin.org/articles/10.3389/fmicb.2012.00116/full
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Conclusion: Carbohydrate-derived fulvic acid has antimicrobial properties against various bacteria and fungi.
Title: Evaluation of carbohydrate-derived fulvic acid (CHD-FA) as a broad-spectrum topical antimicrobial for drug-resistant wound infections
Document Type: Technical Report
Conclusion: We completed the objectives of specific objective 1 of the award statement of work by determining the in vitro susceptibility of CHD-FA against a collection of Acinetobacter baumanii, Pseudomonas aeruginosa, carbapenamase-resistant Klebsiella pneumoniae, Enterococcus faecium, multidrug-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Enterobacter spp., other clinically important species, as well as azole-resistant pathogenic fungi Candida spp., Aspergillus fumigatus and polyene-resistant non-fumigatus Aspergillus species, Fusarium species, and Zygomycetes. Most bacteria show complete growth inhibition at 0.06–0.125% fulvic acid, while efficacy against fungi is 0.125–0.5%.
Link: https://apps.dtic.mil/sti/citations/AD1006071
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Conclusion: Fulvic acid has antibacterial and antifungal properties.
Title: New strategic insights into fungal biofilm management
Document Type: Review Article
Conclusion: Oxyfulvic acid, a derivative of fulvic acid, has been shown to produce antibacterial and antifungal properties. However, these formulations contain numerous toxic elements that make their use clinically impossible. Recently, a pure form of fulvic acid, carbohydrate-derived fulvic acid (CHD-FA), has been developed, which has been shown to be safe to use clinically and to be absent of environmental effects.
contaminants that are known to be harmful to the host.
Link: https://sci-hub.se/10.3389/fmicb.2015.01077
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Conclusion: Fulvic acid can be used to treat bacterial infections, including those caused by antibiotic-resistant bacteria.
Title: Combination of fulvic acid and antibiotics.
Document Type: Patent
Conclusion: This invention relates to a combination of fulvic acid and antibiotic for use in the treatment of various diseases and conditions. The invention further relates to the use of the combination for the treatment of various diseases and conditions, including bacterial infection. In particular, bacteria are antibiotic-resistant bacteria.
Link: https://patents.google.com/patent/EP2317998A1/en
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Conclusion: Fulvic acid has antiviral, antifungal, antioxidant and antibiotic properties.
Title: Natural products as antifungals
Document Type: Book Chapter
Conclusion: Kurobane et al. (1981) reported that Penicillium brefeldianum produces fulvic acid. This compound has been found to exhibit antiviral, antifungal, antioxidant and antibiotic activities.
Link: https://sci-hub.se/https://www.sciencedirect.com/science/article/pii/B9780128158241000044
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Conclusion: Fulvic acids have antifungal and antibacterial properties.
Title: Preparation and research of fulvic acid and its complex metal derivatives with their application.
Document Type: Peer-Reviewed Journal Article
Conclusion: Antimicrobial activity testing revealed that fulvic acid-metal complexes recorded activity against Candida albicans fungi. In contrast, most of the compounds were found to exhibit antibacterial activity against other types of microbes tested including Escherichia coli and Streptococcus pneumoniae.
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Conclusion: Fulvic acid can be used to treat infections caused by multidrug-resistant bacteria.
Title: Combination of fulvic acid and antibiotics for the inhibition or treatment of multi-resistant bacteria
Document Type: Patent
Conclusion: Fulvic acid as an active ingredient is used in the treatment or inhibition of multidrug-resistant bacteria, in particular carbapenemase-producing NDM-1 bacteria or extended-spectrum β-lactamase-resistant (ES8L) bacteria. Multidrug-resistant bacteria may be Gram-negative bacteria including, but not limited to, Klebsiella pneumoniae or Escherichia coli. Fulvic acid may be administered in combination with one or more antibiotics of the carbapenem class or polymyxin antibiotics.
Link: https://patentscope.wipo.int/search/en/detail.jsf?docId=US130253547
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Conclusion: Fulvic acid has antibacterial properties.
Title: Bacteriostatic and bactericidal composition.
Document Type: Patent
Conclusion: A composition having bactericidal or bacteriostatic properties comprises carbon-derived fulvic acid or a salt or derivative thereof as an active ingredient in a suitable vehicle. The vehicle is preferably water.
Link: https://patents.google.com/patent/GB2244215A/en
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Conclusion: Fulvic acid can be used to treat fungal infections.
Title: Fulvic acid in combination with fluconazole or amphotericin B for the treatment of fungal infections
Document Type: Patent
Conclusion: A combination of fulvic acid or a salt, ester or derivative thereof and an antifungal compound selected from fluconazole and amphotericin B is described for use in the treatment or prophylaxis of a disease or condition of the human or animal body. The fulvic acid may be carbohydrate-derived fulvic acid (CHD-FA).
Link: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2010082182
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Conclusion: Humic acid has antibacterial properties.
Title: Composition that has bactericidal or bacteriostatic activity.
Document Type: Patent
Conclusion: A composition having bactericidal or bacteriostatic properties comprising humic acid or a salt or derivative thereof as an active ingredient in a suitable carrier. The active ingredient is preferably an alkali metal salt of humic acid and the carrier is preferably water.
Link: https://patents.google.com/patent/US4999202A/en?oq=US4999202
