Antifungal studies
Conclusion: Fulvic acid shows antifungal properties.
Title: Carbohydrate-derived fulvic acid: an in vitro investigation of a novel membrane-active antiseptic agent against Candida albicans biofilms.
Document Type: Peer-Reviewed Journal Article
Conclusion: This study evaluated the antifungal activity of carbohydrate-derived fulvic acid (CHD-FA) against Candida albicans and characterized its mode of action. CHD-FA was shown to be active against C. albicans in both its planktonic and sessile forms, with effective concentrations of 0.125% and 0.25% respectively. It acted as a fungicide by disrupting cell membrane activity. These results suggest that CHD-FA is a promising natural antiseptic, with a broad spectrum of in vitro activity and minimal biofilm resistance. Further studies are required to determine its clinical applicability.
Link: Frontiers in Microbiology
Conclusion: Carbohydrate-derived fulvic acid has antimicrobial properties against various bacteria and fungi.
Title: Evaluation of carbohydrate-derived fulvic acid (CHD-FA) as a broad-spectrum topical antimicrobial for drug-resistant wound infections.
Document Type: Technical Report
Conclusion: This report confirmed that CHD-FA displays in vitro susceptibility against multiple drug-resistant bacteria, including Acinetobacter baumanii , Pseudomonas aeruginosa , carbapenemase-resistant Klebsiella pneumoniae , Enterococcus faecium , and methicillin-resistant Staphylococcus aureus (MRSA). It also showed efficacy against resistant pathogenic fungi such as Candida spp. , Aspergillus fumigatus , and Fusarium species . Bacterial growth inhibition was observed at concentrations ranging from 0.06% to 0.125%, while efficacy against fungi ranged from 0.125% to 0.5%.
Link: DTIC Citation
Conclusion: Fulvic acid has antibacterial and antifungal properties.
Title: New strategic insights into fungal biofilm management.
Document Type: Review Article
Conclusion: Oxyfulvic acid, a derivative of fulvic acid, has demonstrated antibacterial and antifungal properties. However, previous formulations contained toxic elements, limiting its clinical use. Recently, a pure form of carbohydrate-derived fulvic acid (CHD-FA) was developed, which has been shown to be safe and free of harmful contaminants for the host.
Link: Sci -Hub
Conclusion: Fulvic acid can be used to treat bacterial infections, including those caused by antibiotic-resistant bacteria.
Title: Combination of fulvic acid and antibiotics.
Document Type: Patent
Conclusion: This invention describes a combination of fulvic acid with antibiotics for treating bacterial infections, including those caused by antibiotic-resistant bacteria. The combination can be applied for a wide range of infectious diseases.
Link: Google Patents
Conclusion: Fulvic acid has antiviral, antifungal, antioxidant and antibiotic properties.
Title: Natural products as antifungals.
Document Type: Book Chapter
Conclusion: Research conducted by Kurobane et al. (1981) found that Penicillium brefeldianum produces fulvic acid, which exhibits antiviral, antifungal, antioxidant and antibiotic properties, showing its broad spectrum of biological applications.
Link: Sci -Hub
Conclusion: Fulvic acids have antifungal and antibacterial properties.
Title: Preparation and research of fulvic acid and its complex metal derivatives with their application.
Document Type: Peer-reviewed journal article
Conclusion: Fulvic acid-metal complexes were shown to exhibit activity against Candida albicans as well as antibacterial properties against other microbes such as Escherichia coli and Streptococcus pneumoniae .
Link: IJSER
Conclusion: Fulvic acid can be used to treat infections caused by multidrug-resistant bacteria.
Title: Combination of fulvic acid and antibiotics for the inhibition or treatment of multi-resistant bacteria.
Document Type: Patent
Conclusion: Fulvic acid can be administered together with antibiotics of the carbapenem or polymyxin classes to treat infections caused by multidrug-resistant bacteria, such as Klebsiella pneumoniae and Escherichia coli .
Link: Patentscope
Conclusion: Fulvic acid has antibacterial properties.
Title: Bacteriostatic and bactericidal composition.
Document Type: Patent
Conclusion: A composition with bactericidal or bacteriostatic properties based on fulvic acid derived from carbon, salt or derivatives in a suitable vehicle such as water.
Link: Google Patents
Conclusion: Fulvic acid can be used to treat fungal infections.
Title: Fulvic acid in combination with fluconazole or amphotericin B for the treatment of fungal infections.
Document Type: Patent
Conclusion: The combined use of fulvic acid (CHD-FA) with antifungals such as fluconazole and amphotericin B is proposed to treat fungal diseases in humans and animals.
Link: Patentscope
Conclusion: Humic acid has antibacterial properties.
Title: Composition that has bactericidal or bacteriostatic activity.
Document Type: Patent
Conclusion: Composition based on humic acid or its derivatives, which acts as a bactericidal or bacteriostatic agent in aqueous vehicles.
Link: Google Patents
