Eczema, Psoriasis and Skin Studies
Why use fulvic acid in skin care products?
Fulvic acid has been shown to be helpful for a wide variety of skin-related conditions:
Psoriasis, eczema, seborrheic keratosis, pruritus and actinic keratosis.
It has antibacterial, antifungal and antiviral properties.
It has anti-inflammatory and anti-allergic properties.
Stimulates healing.
Useful in the treatment of allergic diseases.
Antimutagenic and anticlastigenic effects, preventing genetic material from mutating: a key factor in preventing skin cancer.
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Conclusion: Fulvic acid may improve the healing of wounds infected with drug-resistant bacteria.
Title: Carbohydrate-derived fulvic acid is a very promising topical agent for enhancing the healing of wounds infected with drug-resistant pathogens.
Document Type: Peer-Reviewed Journal Article
Conclusion: Carbohydrate-derived fulvic acid (CHD-FA) showed strong activity against a variety of bacterial and fungal pathogens with minimum inhibitory concentration values equal to or less than 0.5%. Compared with infected but untreated wounds, improved wound healing was observed with CHD-FA treatment in both infection models, as demonstrated by wound surface area measurement, histopathological examination, and wound healing gene expression profiling. Upregulation of the pro-inflammatory cytokine interleukin 6 (IL-6) on day 3 postinfection was significantly reduced on days 6 and 10 in CHD-FA-treated wounds in both infection models, showing enhanced and accelerated wound healing. CHD-FA is a promising topical remedy for drug-resistant wound infections. It accelerated the healing process of wounds infected with methicillin-resistant S. aureus and multidrug-resistant P. aeruginosa in rats, which is related to its antimicrobial and anti-inflammatory properties.
Link: https://sci-hub.hkvisa.net/10.1097/ta.0000000000000737
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Conclusion: Fulvic acid may accelerate wound healing.
Title: Investigation of the antioxidant and wound healing activity of fulvic acid in vitro
Document Type: Peer-Reviewed Journal Article
Conclusion: This study aimed to investigate the in vitro antioxidant and wound healing activities of fulvic acid (FA) purified from leonardite from Hüsamlar in Muğla, Turkey. Concentrations of 1, 5, 10, 20, 30, 50, 100 μg ml-1 of FA were tested for antioxidant activity (by using DPPH radical scavenging and H2O2 scavenging assays). Furthermore, the effect of FA on human foreskin fibroblasts BJ and spontaneously immortalized non-tumorigenic human keratinocyte proliferation HaCaT was tested by in vitro MTT and WST-8 assays and on cell migration by wound healing assay (scratch assay). The results of the study show that FA has low DPPH radical scavenging activity, but exhibited high H2O2 scavenging activity at low concentrations. The effect of FA on BJ and HaCaT cell proliferation varied depending on cell type, FA concentration, and treatment time. However, it accelerated wound healing by increasing cell migration, especially in HaCaT cells. 1 and 10 μg mL-1 of FA had a significant wound healing effect on BJ cells, and all FA concentrations had a significant wound healing effect on HaCaT cells at the end of 24 h treatments.
Link: https://dergipark.org.tr/en/pub/jist/issue/47916/509971
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Conclusion: Carbohydrate-derived fulvic acid may be effective in treating staphylococcal infections.
Title: An investigation of the topical and systemic safety and efficacy of a novel carbohydrate-derived fulvic acid (CHD-FA) product
Document Type: Master's Thesis
Conclusion: CHD-FA has been shown to be safe and effective in the treatment of Staphylococcus aureus infections in vitro.
Link: https://repository.up.ac.za/handle/2263/29191
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Conclusion: Fulvic acids help treat eczema, acne, and bacterial, fungal, and viral infections.
Title: Fulvic acid and its use in the treatment of various conditions.
Document Type: Patent
Conclusion: Fulvic acid salts, esters or derivatives in pharmaceutical preparations are effective in treating inflammation, acne, eczema or bacterial, fungal or viral infections. These pharmaceutical preparations can be administered orally or topically in the form of a solution, paste, ointment or powder to humans or animals.
Link: https://patents.google.com/patent/US6569900B1/en
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Conclusion: Fulvic acid, applied topically, could be an effective and safe treatment for skin infections.
Title: An in vitro investigation of the antimicrobial activity of oxyfulvic acid.
Document Type: Peer-Reviewed Journal Article
Conclusion: Oxyfulvic acid has been shown to be effective in the topical treatment of pyrotraumatic dermatitis in dogs and cats and also inhibits contact hypersensitivity in mice. The antimicrobial properties, together with its anti-inflammatory properties, suggest that oxyfulvic acid, applied topically, could be an effective and safe treatment for skin infections.
Link: https://sci-hub.hkvisa.net/10.1093/jac/46.5.853
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Conclusion: Fulvic acid may help in the treatment of eczema.
Randomized, parallel-group, double-blind, controlled study to evaluate the efficacy and safety of carbohydrate-derived fulvic acid in the topical treatment of eczema.
Document Type: Peer-Reviewed Journal Article
Conclusion: The purpose of this study was to evaluate the efficacy and safety of carbohydrate-derived fulvic acid (CHD-FA) in the treatment of eczema in patients aged two years or older. CHD-FA was well tolerated, with no differences in reported side effects other than a short-lived burning sensation following application. CHD-FA significantly improved some aspects of eczema. The investigators' assessment of the overall response to CHD-FA treatment was significantly better than that to emollient therapy alone. The results of this small exploratory study suggest that CHD-FA warrants further investigation in the treatment of eczema.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173016/
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Conclusion: Fulvic acid may protect against ulcers.
Title: Antiulcerogenic activity of fulvic acids and 4′-methoxy-6-carbomethoxybiphenyl isolated from shilajit
Document Type: Peer-Reviewed Journal Article
Conclusion: Shilajit components, fulvic acid (FA) and MCB, significantly reduced the incidence of duodenal ulcer in the experimental model.
Link: https://sci-hub.hkvisa.net/10.1002/ptr.2650020408
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Conclusion: Fulvic acid has anti-inflammatory properties in topical applications.
Title: Pilot study to evaluate the safety and therapeutic efficacy of topical oxyfulvic acid in atopic volunteers
Document Type: Peer-Reviewed Journal Article
Conclusion: Oxyfulvic acid has demonstrated anti-inflammatory properties in vitro. Topically applied oxyfulvic acid had no significant effect on any of the safety parameters and did not induce sensitization when applied to the skin. Oxyfulvic acid (4.5%) caused inhibition of the inflammatory reaction elicited at 15 minutes and differed significantly from the 9% cream at 24 h.
Link: https://sci-hub.hkvisa.net/10.1002/ddr.10116
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Conclusion: Humic acid may improve wound healing.
Title: Natural Products and/or Isolated Compounds on Wound Healing
Document Type: Peer-Reviewed Journal Article
Conclusion: Overall, the results of this study showed that humic acid, which has previously been shown to have antibacterial and anti-inflammatory properties, improves wound healing in the oral cavity. Treatment with humic acid was even superior to chlorhexidine gluconate, which is widely used for the treatment of oral wounds. To our knowledge, this is the first study to demonstrate that treatment with humic acids can be used for the treatment of wounds in the oral cavity.
Link: https://www.hindawi.com/journals/ecam/2018/1783513/
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Conclusion: Fulvic acid has anti-inflammatory properties and may help treat inflammatory skin conditions.
Title: Topical application of oxyfulvic acid suppresses cutaneous immune response in mice
Document Type: Peer-Reviewed Journal Article
Conclusion: The anti-inflammatory activity of topically applied coal-derived fulvic acids (called oxyfulvic acid) at 4.5% and 9% concentrations was compared with that of 1% diclofen sodium and 0.1% betamethasone in a murine model of contact hypersensitivity. Oxyfulvic acid at both concentrations compared favorably with diclofen sodium and betamethasone in suppressing the cutaneous inflammatory response. Oxyfulvic acid possesses anti-inflammatory properties and may be of clinical benefit in the treatment of inflammatory skin conditions in humans.
Link: https://sci-hub.hkvisa.net/10.1002/ddr.1166
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Conclusion: Fulvic acid compositions administered orally or topically may help treat inflammation, microbial infections, acne, and eczema.
Title: Fulvic acid and its use in the treatment of inflammation.
Document Type: Patent
Conclusion: Disclosed is a pharmaceutical composition comprising fulvic acid, salt, ester or derivative thereof as an active agent. The composition is preferably administered orally or topically to treat a condition in a human or animal. The condition may be, for example, inflammation, acne, eczema or bacterial, fungal or viral infections.
Link: https://patents.google.com/patent/EP1700600A1/en
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Conclusion: Compositions containing humic substances help treat various diseases and conditions, including wounds, inflammation, infections, and allergies.
Title: Compositions and treatment methods using peat derivatives.
Document Type: Patent
Conclusion: Novel compositions containing at least one biologically active component derived from peat or a similar composition, methods for their preparation, and therapeutic uses for a variety of diseases, injuries, and conditions including wound healing, pain, itching, inflammation, abnormal cell proliferation, or infections caused by fungal, bacterial, rickettsial, or viral agents, psoriasis, allergic and other dermatitis, pruritus, eczema, actinic keratosis, and similar conditions. In addition, the compositions can be used as diuretics, antiarrhythmics, and cardiac stimulating agents, as well as for the treatment of mammalian diseases and disorders including multidrug resistance, cancers, asthma, rheumatoid arthritis, pain, wound healing, fungal disorders, and other inflammatory disorders. The compositions are derived from peat or peat-related substances, and alternatively can be produced synthetically.
Link: https://patents.google.com/patent/US6267962B1/en
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Conclusion: Fulvic and ulmic acids penetrate the skin and stimulate muscle activity.
Title: Fulvic acid and its use in the treatment of inflammation.
Document Type: Peer-Reviewed Journal Article
Conclusion: HPLC analysis revealed that aqueous extracts of peat contain up to 18 fractions of water-soluble compounds of fulvic and ulmic acids. These compounds have been found to have a stimulatory response on the contractile activity of SM tissue. In vitro diffusion studies demonstrated that the permeability of these substances through full-thickness human skin (thickness: 200 um(-1)) is highly selective and the resulting stimulatory activity depends on the permeated fraction. Especially, HPLC fractions 7-11 and 14 are able to penetrate human skin. Fractions 7-11 show a moderate stimulatory effect of SCA on SM for more than 90 minutes, while fraction 14 shows the strongest stimulatory effect which, however, was suppressed after 87 minutes. These results show that skin therapy with peat treatment produces transcutaneous permeation of biologically active derivatives of fulvic and ulmic acids, which explains the additional "chemical" effect of peat treatment in clinical practice.
Link: https://sci-hub.hkvisa.net/10.1016/s0378-5173(02)00706-8
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Conclusion: Shilajit compositions, containing fulvic acids, are useful in personal care, pharmaceutical and nutritional applications.
Title: Process for preparing a purified shilajit composition from native shilajit
Document Type: Patent
Conclusion: Provided herein is a purified shilajit composition made from native shilajit. The composition has a high amount of bioactive components, particularly, at least 0.3%, preferably 0.4-1%, by weight, of oxygenated dibenzo-α-pyrones and at least 60%, preferably 65-70%, by weight of low-oxygen fulvic acids of medium to medium molecular weight, and whose 2% aqueous solution has a pH ≥7. Also described are formulations for personal care, pharmaceutical and nutritional use of the purified shilajit composition.
