Liver Function Studies
Bibliographic support on the role of fulvic acid and humic acid in improving liver function
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Effect of humic substances on mitochondrial respiration and oxidative phosphorylation.
Conclusion: Fulvic and humic acids stimulate liver cell respiration.
Article type: Original research
Abstract: Fulvic and humic acids extracted from a podzol were shown to stimulate respiration in rat liver mitochondria when present at concentrations between 40 and 360 mg L −1 . Low molecular weight fractions induced a more significant increase in respiration than high molecular weight material.
https://sci-hub.se/https://www.sciencedirect.com/science/article/abs/pii/0048969787905213
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Experimental basis and prospects for the use of humic acid preparations from peat in medicine and agricultural production.
(Note: the original article is in Russian)
Conclusion: Humic acid may support liver function and protect against liver disease.
Article type: Original research
Abstract: Humate plays a role in liver function and protects to some extent from diseases and/or disorders.
https://pubmed.ncbi.nlm.nih.gov/1665990/
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An examination of humate-stimulated liver functions.
(Note: the original article is in Polish)
Conclusion: Prolonged application of humic acid may help in liver regeneration.
Article type: Original research
Abstract: The effect of natural humic acid on the regenerative response of liver tissue in rats subjected to two-thirds hepatectomy was examined. Long-term application of humic acid resulted in stimulation of ornithine decarboxylase, increased spermidine and histamine levels, as well as RNA and DNA levels, and overall liver mass.
https://patents.google.com/patent/US5945446A/en
(The original citation is: Maslinski , C. , Fogel , W. A. , & Andrzejewski , W. ( 1993 ): An examination of humate-stimulated liver functions . Acta Pol . Pharm ., 50 ( 4-5): 413-416; since the original link was not available, this is the link to a patent that cites the original article and describes its results)
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Humic and fulvic acids alleviate hydrogen peroxide-induced oxidative damage
Conclusion: Humic and fulvic acids may protect the liver against oxidative damage.
Article type: Original research
Abstract: The protective effect of humic acid and fulvic acid against oxidative stress and induced liver damage in rats was evaluated by estimating SOD, GPx activity, and MDA levels. The results revealed that the administered humic acid and fulvic acid showed a significant reduction in both enzymes, indicating their protective effects against induced oxidative damage, through modulation of the defense enzymes GPx and SOD. Fulvic acid exhibited a more potent protective activity at a dose of 150 mg/kg.
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Effect of fulvic and humic acids on iron and manganese homeostasis in rats.
Conclusion: Fulvic acid may improve iron levels in the liver.
Article type: Original research
Abstract: In a study in rats, fulvic acid (FA) was shown to be a good source of iron and slightly increased iron content in the liver and kidneys, but (up to a dietary iron level of 52.7 mg/kg) did not influence the efficiency of iron absorption.
https://akjournals.com/view/journals/004/65/1/article-p66.xml
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Research on the biological effects of fulvic and humic acids in rats.
Conclusion: Fulvic and humic acids can improve the level of copper mineral in the liver.
Type of article: Doctoral Thesis
Abstract: In this study on rats, liver copper content was significantly increased by 0.2% and 0.8% fulvic acid (FA) supplementation. Meanwhile, the group receiving 0.1% humic acid supplement had higher copper content, but the 0.2% group had reduced copper content in the liver.
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The acute effect of humic acid on iron accumulation in rats.
Conclusion: Humic acid may protect against iron-induced liver toxicity through its antioxidant properties.
Article type: Original research
Abstract: This study demonstrated that humic acid (HA) protected against iron-induced hepatotoxicity and cardiotoxicity through its antioxidant and free radical scavenging effects at both histopathological and biochemical levels. Presumably, it exerts this effect by reducing ROS activity through antioxidant features such as inhibition of lipid peroxidation and enhanced enzymatic and non-enzymatic antioxidant systems. It is possible that HA can be used as a protective agent against iron-induced liver and cardiac injury. However, further clinical studies are needed to demonstrate the protective effects of HA against iron-induced hepatotoxicity and cardiotoxicity.
https://sci-hub.ru/10.1007/s12011-015-0507-0
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Evaluation of humic acid as an aflatoxin chelator in broiler chickens
Conclusion: Humic acid may protect against liver damage caused by toxins such as aflatoxins.
Article type: Original research
Abstract: The efficacy of humic acid (HA) as an aflatoxin (AF) chelator was evaluated in broiler chickens exposed to aflatoxin-contaminated feed from 1 to 42 days of age. Oxyhumate was effective in decreasing the adverse effects caused by aflatoxins on body weight (BW) of broiler chickens. Humic acid also showed protective effects against liver damage and some of the hematological and serum biochemical changes associated with aflatoxin toxicity. HA supplementation also enhanced humoral immunity by counteracting aflatoxin contamination. The results indicated that HA could alleviate some of the toxic effects of aflatoxins in growing broiler chickens. Therefore, humic acid (0.1 to 0.3%) could be beneficial in the management of aflatoxin-contaminated poultry feed when used in combination with other mycotoxin management practices.
https://sciente.com/pdf/10.1515/aoas-2016-0050
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Study on the effect of humic acid on growth performance, immunology, some blood parameters and intestinal control of Clostridium in broiler chickens.
Conclusion: Humic acid may decrease liver enzyme levels that are elevated during infection.
Article type: Original research
Abstract: Humic acid induced a significant reduction of liver enzymes and metabolites such as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatases and an insignificant decrease in uric acid and creatinine in broiler chickens, which are otherwise increased in case of infection.
https://zvjz.journals.ekb.eg/article_29352.html
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Effects of fulvic acid addition on laying performance, biochemical indices and intestinal microbiota of aged hens
Conclusion: Humic and fulvic acids may protect the liver by reducing oxidative stress.
Article type: Original research
Abstract: The existence of serum enzymes and their levels in the blood can help determine the extent of organ or tissue damage. Because they are synthesized in the liver, ALT, AST, and total bilirubin are essential indices for monitoring liver function in chickens. Diets containing potassium humate had lower AST values than diets containing 17.5% canola meal. In this study in chickens, fulvic acid was found to be able to reduce serum AST levels and tended to decrease total bilirubin. This may indicate that humic acid may protect the liver by reducing free radicals produced during hepatic metabolism.
https://www.frontiersin.org/articles/10.3389/fvets.2022.953564/full
