Liver Function Studies

Fulvic and Humic Acid as Protective and Repairing Agents for Liver Function

Humic and fulvic acids are natural compounds with antioxidant, anti-inflammatory, and chelating properties that have demonstrated a positive impact on protecting and improving liver function. Animal and human studies highlight their ability to stimulate essential cellular processes, mitigate oxidative damage, regulate essential mineral levels, and reduce the toxicity of harmful substances such as heavy metals and mycotoxins. Below is key research supporting the role of these compounds in liver health.

1. Stimulation of Liver Respiration

Title: Effect of humic substances on mitochondrial respiration and oxidative phosphorylation.
Conclusion: Humic and fulvic acids stimulate respiration in rat liver mitochondria at specific concentrations, with low molecular weight fractions showing greater efficacy.
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2. Protection Against Liver Diseases

Title: Experimental basis and prospects for the use of humic acid preparations from peat in medicine and agricultural production.
Conclusion: Humic acid plays a protective role against liver diseases and improves liver function.
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3. Liver Regeneration

Title: An examination of the hepatic functions stimulated by humates.
Conclusion: Prolonged application of humic acid stimulates regenerative processes of the liver, such as increased levels of RNA, DNA and liver mass, in rats subjected to partial hepatectomy.
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4. Protection Against Oxidative Damage

Title: Humic and fulvic acids alleviate hydrogen peroxide-induced oxidative damage.
Conclusion: Both acids protect the liver against oxidative damage, modulating antioxidant enzymes such as SOD and GPx, with fulvic acid showing greater efficacy at specific doses.
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5. Regulation of Essential Minerals

Title: Effect of fulvic and humic acids on iron and manganese homeostasis in rats.
Conclusion: Fulvic acid slightly increases iron levels in the liver without significantly affecting its absorption.
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6. Reduction of Liver Toxicity

Title: The acute effect of humic acid on iron accumulation in rats.
Conclusion: Humic acid protects against iron-induced liver toxicity thanks to its antioxidant properties, reducing oxidative stress and lipid peroxidation.
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7. Neutralization of Toxins such as Aflatoxins

Title: Evaluation of humic acid as an aflatoxin chelator in broiler chickens.
Conclusion: Humic acid reduces liver damage caused by aflatoxins, improves biochemical parameters and strengthens the immune response.
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8. Decreased Liver Enzymes During Infections

Title: Study on the effect of humic acid on growth performance, immunology, some blood parameters and intestinal control of Clostridium in broiler chickens.
Conclusion: Humic acid reduces elevated levels of liver enzymes such as AST, ALT and alkaline phosphatases during infections.
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9. Liver Protection in Chickens

Title: Effects of fulvic acid addition on laying performance, biochemical indices and intestinal microbiota of aged hens.
Conclusion: Humic acid and fulvic acid protect the liver by reducing AST and total bilirubin levels, indicating less oxidative stress in the organ.
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General Summary

Humic and fulvic acids have been shown to be effective in protecting and improving liver function in several studies. Their ability to mitigate oxidative stress, improve mineral homeostasis, protect against toxins and promote regenerative processes makes them promising natural allies for liver health.