Inflammation Studies
Anti-inflammatory Properties of Humic and Fulvic Substances
Humic and fulvic substances have been shown to be effective in reducing inflammation through various biological mechanisms. These anti-inflammatory properties are supported by scientific research highlighting their potential to treat various inflammatory conditions, improve involuntary muscle activity, and act as safe agents at appropriate doses. Here we present a review of the most relevant studies on this topic.
1. Anti-inflammatory Properties of Humic Substances
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Title: Anti-inflammatory properties of humic substances: a mini review
Conclusion: Humic substances are effective in suppressing inflammatory responses such as delayed-type hypersensitivity and edema in animal models. In addition, they reduce C-reactive protein levels in humans with osteoarthritis and hay fever. Their anti-inflammatory action is associated with the inhibition of inflammatory cytokines and adhesion molecules. Toxicity studies indicate that they are safe at doses up to 1 g/kg for potassium humate and 1.8 g per adult for fulvic acid.
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2. Properties of Fulvic Acid Derived from Carbohydrates
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Title: Phase 1 clinical study on acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid
Conclusion: Carbohydrate-derived fulvic acid (CHD-FA) is safe at doses up to 40 ml twice daily for one week. At these doses, CHD-FA acts as an effective anti-inflammatory agent, with no serious adverse events reported.
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3. Dose-Dependent Effects of Humic Substances
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Title: Dose-dependent effects of different humic substances in preclinical test systems
Conclusion: Humic substances show dose-dependent effects. At low concentrations, they enhance spontaneous contractile activity of smooth muscles by stimulating alpha(2) adrenoceptors and dopamine D2 receptors. At intermediate concentrations, they inhibit the release of TNF-alpha, a key inflammatory marker. At high concentrations, they act as anticoagulants.
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Summary
Humic and fulvic substances offer a promising approach to safely and effectively address inflammation. From suppressing inflammatory cytokines to improving muscle activity and reducing inflammatory markers in humans, these natural substances represent a valuable resource in complementary and preventative medicine.
