Inflammation Studies

Conclusion: Humic substances have anti-inflammatory properties.

Title: Anti-inflammatory properties of humic substances: a mini review

Document Type: Peer-Reviewed Journal Article

Conclusion: Humic substances are effective in suppressing delayed-type hypersensitivity, rat paw edema, graft-versus-host reaction, and contact hypersensitivity in rats. They reduce C-reactive protein levels in patients suffering from knee and wheel osteoarthritis and inflammation reaction in patients suffering from hay fever. They have also been described as cardioprotective and proangiogenic. Toxicity studies have indicated that potassium humate is safe in humans up to a daily dose of 1 g/kg, while fulvic acid is safe in humans up to a daily dose of 1.8 g per adult. The anti-inflammatory action of potassium humate may be attributed to the inhibition of the release of inflammation-related cytokines, an adhesion molecule, oxidants, and components of the complement system.

Link: https://sci-hub.hkvisa.net/10.1002/ptr.5319

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Conclusion: Carbohydrate-derived fulvic acid has anti-inflammatory properties.

Title: Phase 1 clinical study on acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid

Document Type: Peer-Reviewed Journal Article

Conclusion: The purpose of this investigation was to determine the acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid (CHD-FA). No serious adverse events occurred, establishing that CHD-FA is safe at doses up to 40 mL twice daily for one week and that at this dose CHD-FA acts as an anti-inflammatory agent.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304339/

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Conclusion: Humic substances may improve involuntary muscle activity and have anti-inflammatory properties.

Title: Dose-dependent effects of different humic substances in preclinical test systems

Document Type: Peer-Reviewed Journal Article

Conclusion: The results show for all applied test systems that humic substances (HS) acted in a dose-dependent manner. At low concentrations (1 to 10 microg/ml), they enhanced the spontaneous contractile activity of smooth muscles by stimulating alpha(2) adrenoceptors and dopamine D2 receptors; at intermediate concentrations (10 to 250 mg/ml), they inhibited the release of TNF-alpha; and at high concentrations (250 to 1000 microg/ml), they acted as anticoagulants.

Link: https://sci-hub.hkvisa.net/https://link.springer.com/chapter/10.1007/978-94-007-5634-2_207