Cancer Studies
Fulvic Acid and Humic Substances: Anticancer Potential and Related Benefits
Conclusion 1: Fulvic acid can induce cancer cell death.
Title: Fulvic acid promotes extracellular anticancer mediators from RAW264.7 cells, causing cancer cell death in vitro.
Document Type: Peer-reviewed journal article.
Summary:
Fulvic acid (FA) stimulates nitric oxide (NO) and iNOS generation in RAW 264.7 cells by activating NF-κB. FA-stimulated culture media increased apoptosis in human cancer cell lines such as Hep3B, LNCaP, and HL60. These results suggest that FA may act as an immunomodulator and promote programmed cell death in tumor cells.
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Conclusion 2: Humic substances may be effective in cancer therapy.
Title: Humic substances as potent biomaterials for therapeutic and drug delivery systems: a review.
Document Type: Peer-reviewed journal article.
Summary:
Research on humic substances (HS) has highlighted their relevance in the formulation of drugs and drug delivery systems. The biochemical and molecular effects of HS suggest that they may be robust candidates for cancer therapy, acting both directly and as an adjuvant in treatments.
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Conclusion 3: Humic acids have anti-cancer and anti-aging properties.
Title: Therapeutic efficacy of humic acids in poisoning.
Document Type: Review article.
Summary:
Humic acids (HA) possess antioxidant activity, which gives them anticancer effects. They can be used as an adjunctive treatment during chemotherapy to protect healthy tissues and mitigate oxidative damage. HAs may also be useful in anti-aging therapies, promoting healing and reducing oxidative stress.
Link: Full article
Conclusion 4: Fulvic acid can kill liver cancer cells.
Title: Antiproliferative and anticancer properties of fulvic acid in liver cancer cells.
Document Type: Peer-reviewed journal article.
Summary:
This study demonstrated that fulvic acid (FA) has anticancer properties by inducing apoptosis and generating reactive oxygen species (ROS). This suggests its usefulness in the treatment of liver cancer and related disorders.
Link: Full Study
Conclusion 5: Humic substances activate the immune system and reduce oxidative stress in liver cancer cells.
Title: Humic substances as environmentally friendly organic waste that help as natural antivirals and COVID-19 inhibitors.
Document Type: Peer-reviewed journal article.
Summary:
Humic substances (HS) act as immune modulators and can induce apoptosis in liver cancer cells. In addition, they reduce proinflammatory markers and improve intestinal health, making them potential candidates for antitumor treatments.
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Conclusion 6: Shilajit induces apoptosis in liver cancer cells.
Title: Mineral pitch induces apoptosis and inhibits proliferation by modulating ROS in liver cancer cells.
Document Type: Peer-reviewed journal article.
Summary:
Shilajit, a resin rich in fulvic and humic acids, induces apoptosis in Huh-7 cells by modulating reactive oxygen species and regulating microRNAs. Its use could be relevant in therapies against liver cancer.
Link: Detailed study
Conclusion 7: Fulvic acid may inhibit the progression of colorectal cancer.
Title: Fulvic acid attenuates resistin-induced adhesion of HCT-116 colorectal cancer cells to endothelial cells.
Document Type: Peer-reviewed journal article.
Summary:
Fulvic acid (FA) reduces NF-κB activation and resistin-induced cell adhesion molecule expression in colorectal cells. This suggests that FA could be a candidate to inhibit colorectal cancer progression.
Link: Full article
Conclusion 8: Humic and fulvic acids have antitumor properties against breast cancer.
Title: Cytotoxic effects of humic acid and fulvic acid on human breast cancer cells.
Document Type: Peer-reviewed journal article.
Summary:
Humic acids (HA) and fulvic acids (FA) induce apoptosis and reduce cell viability in breast cancer cells (MCF-7). These compounds show potential as anticancer therapeutic agents.
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Conclusion 9: Fulvic acid could be useful in the treatment of skin cancer (melanoma).
Title: Activation of apoptosis and cell cycle arrest by humic and fulvic acid in A375 human melanoma cells.
Document Type: Peer-reviewed journal article.
Summary:
Humic acid (HA) and fulvic acid (FA) activate pro-apoptotic pathways in human melanoma cells. Furthermore, they inhibit melanogenesis, making them promising agents for antitumor treatments.
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General Conclusion
Humic and fulvic acids, along with their derivatives, display a broad spectrum of anticancer activities, from induction of apoptosis to inhibition of cell proliferation in various types of cancer. These compounds are promising candidates for future research and clinical applications in oncology.
