Cancer Studies
Conclusion: Fulvic acid can induce the death of cancer cells.
Title: Fulvic acid promotes extracellular anticancer mediators from RAW264.7 cells, causing cancer cell death in vitro
Document Type: Peer-Reviewed Journal Article
Conclusion: Fulvic acid (FA) induces NO and iNOS generation in RAW 264.7 cells by inducing NF-κB activation. Moreover, FA-stimulated culture media enhanced cell death in several human cancer cells such as Hep3B, LNCaP, and HL60. Taken together, FA most likely stimulates immunomodulatory molecules such as NO and induces cancer cell apoptosis.
Link: https://fulvic.info//wp-content/uploads/2019/01/M-Cancer-cell-death-study1-RMIT-1-1.pdf
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Conclusion: Humic substances may be effective in cancer therapy.
Title: Humic substances as potent biomaterials for therapeutic and drug delivery systems: a review
Document Type: Peer-Reviewed Journal Article
Takeaway: The researches on humic substances still have great relevance in drug formulation and drug delivery system. Based on the collective indication of the biochemical and molecular effects of humic substances may make them robust candidates for cancer therapy.
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Conclusion: Humic acids have anti-cancer and anti-aging properties and may help protect against toxicity caused by iron, lead, copper, and mycotoxins.
Title: Therapeutic Efficiency of Humic Acids in Intoxications
Type of Article: Review Article
Summary: Humic acids (HAs) possess antioxidant activity. This property also gives HAs their anti-cancer effect. Furthermore, the administration of HAs can be useful as a supportive treatment alongside cancer chemotherapy, where it protects tissue cells around the application of chemotherapeutics and prevents (mitigates) oxidative damage to these cells. Antioxidant effects of HAs can also be beneficial in anti-aging therapy, lowering social stress, and promoting wound healing, as well as in protecting against iron-induced hepatotoxicity and cardiotoxicity. Additionally, HAs can protect against lead and copper poisoning, mycotoxins, and other toxicants.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143271/
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Conclusion: Formulations containing fulvic acid may have anticancer properties.
Title: Composition of nutritional supplement for the treatment of coronavirus infections, cancer, MS, chronic and post-viral fatigue syndrome and neurodegeneration in an individual
Document Type: Patent
Conclusion: A chemopreventive and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, enhancing immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising NMN, NAD, PQQ, CoQ10, piperine, vitamin B7, vitamin B9, and vitamin B12. Further disclosed is a chemopreventive and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, enhancing immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising resveratrol. Pterostilbene, Quercetin, Baikal Skullcap, L-Theanine, Curcuminoids (Turmeric Extract), Lion's Mane Mushroom, Vitamin B1, Vitamin B2, Vitamin B5, Vitamin B6, Piperine, and Zinc Complex. Additionally disclosed is a chemopreventive and cytotoxic formulation to treat coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, enhance immune, mitochondrial, stem cell, and brain function, and reverse epigenetic aging, in an individual, comprising alpha lipoic acid. (ALA), Acetyl-L-Carnitine (ALCAR), N-Acetyl Cysteine (NAC), Ginkgo Biloba, Beta-Glucans, Epigallocatechin-3-Gallate (EGCG), Green Tea Extract, Pomegranate Extract (including Ellagic Acid), Olive Leaf Extract (incl. Oleuropein and Hydroxytyrosol), Green Coffee Bean Extract (incl. Chlorogenic Acids), Theacrine, Piperine, and additionally humic and fulvic acids in some embodiments.
Link: https://patents.google.com/patent/GB2596849A
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Conclusion: Fulvic acid can kill liver cancer cells.
Title: Anti-Proliferative and Anticancer Properties of Fulvic Acid on Hepatic Cancer Cells
Type of Document: Peer-reviewed journal article
Takeaway: This study showed that fulvic acid (FA) has the anticancer properties by increasing apoptosis and via production of nitric acid and reactive oxygen species. Our study demonstrated that fulvic acid may be useful in liver cancer and related disorders.
Link: https://sci-hub.se/https://www.jcehepatology.com/article/S0973-6883(15)00118-8/fulltext
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Conclusion: Humic substances may activate the immune system, reduce oxidative stress and kill liver cancer cells.
Title: Humic substances as an environmental- friendly organic wastes potentially help as natural anti-virus to inhibit COVID-19
Type of Document: Peer-reviewed journal article
Takeaway: The information gathered in this review indicates that humic substances (HS) can act as an immune modulator, influence the redox state, and potentially affect gut health. HS is shown to decrease pro-inflammatory markers but also activate the immune system to inhibit COVID-19. It is shown to reduce oxidative stress and even induce apoptosis in hepatic cancer lines.
Link: www.sciencearchives.org/wp-content/uploads/2020/09/Science-Archives-2020-Vol.-1-2-53-60.pdf
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Conclusion: Shilajit may induce the death of liver cancer cells.
Title: Mineral pitch induces apoptosis and inhibits proliferation by modulating reactive oxygen species in liver cancer cells.
Document Type: Peer-Reviewed Journal Article
Conclusion: The data clearly indicate that Mineral Pitch or Shilajit induced apoptosis through ROS production and inhibited proliferation by inducing miRNA-22 and inhibiting miRNA-21 in Huh-7 cells.
Link: https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1131-z
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Conclusion: Fulvic acid may hinder the progression of colorectal cancer.
Title: Fulvic acid attenuates resistin-induced adhesion of HCT-116 colorectal cancer cells to endothelial cells
Document Type: Peer-Reviewed Journal Article
Conclusion: Resistin may play a role in the development of colorectal cancer (CRC). Fulvic acid (FA), a class of humic substances, possesses pharmacological properties. Co-treatment of cells with FA and resistin revealed that FA significantly attenuated resistin-enhanced NF-κB activation and ICAM-1/VCAM-1 expression and the subsequent adhesion of HCT-116 cells to HUVECs. These results demonstrate the role of resistin in promoting adhesion of HCT-116 cells to HUVECs and indicate that FA might be a potential candidate for inhibition of CRC endothelial adhesion in response to resistin.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691117/
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Conclusion: Shilajit has anti-inflammatory, anti-oxidative, anti-cancer, and immunomodulatory properties.
Title: Shilajit in Cancer Treatment: Probable Mode of Action
Type of Document: Peer-reviewed journal article
Takeaway: Humic and fulvic acid have been reported to possess cancer preventive properties. It has been shown that these compounds can inhibit mutagenesis and have free radicals scavenging, photo-protecting, anti-inflammatory and toxic compound removing properties that can inhibit cancer development. Shilajit is a non-expensive, non-toxic compound which can be taken orally. Therefore, it is rational that future clinical studies should focus on examining the efficacy of Shilajit and its active constituents in cancer prevention as an alternative pharmacological agent. In this review, we address the use of Shilajit and its constituents for the prevention and management of cancer. Shilajit is one such compound, which has been used in Ayurveda for centuries. The humic compounds of Shilajit can be a potential cancer preventive agent. Anti-inflammatory, anti-oxidative, anti-mutagenic, immunomodulatory and several other effects of Shilajit have already been reported.
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Conclusion: Shilajit may be useful in cancer treatment and prevention.
Title: Shilajit: A Humic cure for Cancer
Type of Document: Peer-reviewed journal article
Takeaway: Shilajit and HA possess anti-inflammatory, antioxidant, antimutagenic, antitoxic, antiviral, heavy metal chelating, antitumor, apoptotic and photo-protective properties. These properties make Shilajit useful agents for cancer therapy and prevention. In addition, Shilajit has no reported side effects and can be administered as a nutritive and rejuvenating tonic and combats age related problems.
Link: https://altermed.com.ua/pdf/shilajit-a-panacea-for-cancer.pdf
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Conclusion: Fulvic acid may inhibit the multiplication of cancer cells and may even cause cancer cell death.
Title: Effects of Fulvic Acid on Different Cancer Cell Lines
Type of Document: Peer-reviewed journal article
Takeaway: Hep3B, HT29 and PC3 cells were treated with different concentrations of fulvic-acid for 48 and 72 h and cell proliferation was performed MTT test. Fulvic-acid inhibited the proliferation of all the cell lines used in this study determined by MTT analysis. Specifically, Hep3B cells were found to be most sensitive for 48-hour application with 1.58–2.43 μg/μL IC50 value. Additionally, fulvic-acid significantly upregulated the apoptotic genes at mRNA levels compared to non-treated control group.
Link: https://doi.org/10.3390/proceedings1101031
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Conclusion: Humic acid can kill breast cancer cells.
Title: The cytotoxic effects of humic acid on human breast cancer cells
Document Type: Peer-Reviewed Journal Article
Conclusion: Humic acid (HA) induces apoptosis and has various pharmacological properties including anti-inflammatory and antiproliferative effects. In our study, we examined the cytotoxic effects of HA at concentrations of 5, 10, 20, 50, and 100 μg/mL on human breast adenocarcinoma cell line MCF-7 for 24 and 48 h. Using the MTT method, 100 μg/mL HA was found to have a cytotoxic effect on human breast adenocarcinoma cell line MCF-7 at both 24 and 48 h; they also found that the effective dose of HA at the same time (24 and 48 h) was 50 μg/mL.
Link: https://doi.org/10.3390/proceedings2251565
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Conclusion: Fulvic acid may hinder the progression of colorectal cancer.
Title: Fulvic acid attenuates resistin-induced adhesion of HCT-116 colorectal cancer cells to endothelial cells
Type of Document: Peer-reviewed journal article
Takeaway: Fulvic acid might be a potential candidate for the inhibition of the endothelial adhesion of colorectal cancer in response to resistancein, a serum compound that plays an important role in the development of this cancer.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691117/
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Conclusion: Humic acid may enhance the anticancer activity of arsenic trioxide in cervical cancer.
Title: Humic acid enhances the cytotoxic effects of arsenic trioxide on human cervical cancer cells
Document Type: Peer-Reviewed Journal Article
Conclusion: Our results showed As2O3- and HA-induced cell growth inhibition, most likely by ROS-mediated cell damage and activation of apoptosis pathway, and HA enhanced the antiproliferative action of As2O3 in HeLa and SiHa cells, which reduced the LC50 from approximately 57.62 or 73.52% (300 μg HA/mL) to 83.67 or 79.03% (500 μg HA/mL), respectively. This study is relevant for the development of chemotherapeutic approaches using As2O3 in the treatment of human cervical cancer.
Link: https://sci-hub.hkvisa.net/10.1016/j.etap.2009.11.009
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Conclusion: Nutritional supplements containing fulvic acid may help treat cancer.
Title: Healthy food supplement
Document Type: Patent
Conclusion: The dietary supplements described herein have no negative side effects and can optimize the health of animals, including humans, receiving them. The supplemental feed contains a number of nutrients including at least four of the following: amino acid blend, fulvic-humic acids, multiminerals, glycerin, phosphatidylinositol, sesquiterpene alkaloids, terpenes, medium chain triglycerides (MCTs), coconut oil, whole plant matter, plant seeds, mushrooms, kelp, seaweed, and flavoring agents. The supplemental feeds have surprising benefits such as reduced incidence and/or severity of disease relative to an animal (or human) not receiving the supplements. Humans and animals receiving the supplements may exhibit disease resistance and enhanced immune responses. Humans and animals receiving the supplements may have less pain, improvement of disease, more energy, better sleep patterns, higher activity levels, less numbness in the extremities, improved digestion, fewer headaches, fewer symptoms, fewer tumors, fewer cancer cells, and/or fewer seizures, compared to their own experience before taking the supplements.
Link: https://patents.google.com/patent/US20200000136A1/
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Conclusion: Modified fulvic acid may act as an anti-cancer drug.
Title: Application of modified fulvic acid in the preparation of antitumor drugs.
Document Type: Patent
Conclusion: The invention describes the application of modified fulvic acid in the preparation of antitumor drugs. A preparation method of the modified fulvic acid comprises the following steps: (1) directionally degrading a raw material containing fulvic acid or fulvic acid in water through HNO3 and H2SO4 to obtain a degradation product of fulvic acid; and (2) under microwave conditions, carrying out the reaction between the degradation product of fulvic acid obtained in step (1) and kojic acid or kojic acid-containing extract to obtain the modified fulvic acid. The application disclosed by the invention, compared with existing treatment drugs, has the advantages of the following three aspects: 1) the modified fulvic acid can be extracted from the peat resource, thereby achieving full use of the resource and protecting the environment; 2) The prepared anti-tumor drugs are rich in raw medicinal resources, and while having the same curative effect as existing treatment drugs, they have a higher cost performance; and 3) The anti-tumor drugs, compared with other Western medicines, have good curative effects and fewer side reactions. The modified fulvic acid preparation described by the invention has good social and economic benefits.
Link: https://patents.google.com/patent/CN103720716A/
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Conclusion: Fulvic acid may help treat skin cancer (melanoma).
Title: Activation of apoptosis and G0/G1 cell cycle arrest together with inhibition of melanogenesis by humic acid and fulvic acid: expression of BAX/BCL-2 and Tyr genes and evaluation of nanomechanical properties in the human melanoma cell line A375
Type of Document: Peer-reviewed journal article
Takeaway: These results exhibited that fulvic acid (FA) and humic acid (HA) possess pro-apoptotic effects through increasing the BAX/ BCL-2 expression in A375 (human melanoma) cells. These molecular reports were confirmed by cellular nanomechanical assessments using AFM and flow cytometry. In addition, HA and FA inhibited melanogenesis by decreasing the expression of the Tyr gene. It is worthwhile to note that, HA and FA can be regarded to design new anti-cancer and anti-melanogenesis products.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150800/
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Conclusion: Fulvic acid may be effective against squamous cell carcinoma (oral cancer).
Title: Evaluating the Effect of Fulvic Acid on Oral Bacteria and Cancerous Oral Cells
Type of Document: Conference poster
Takeaway: To evaluate the effect of fulvic acid on human squamous cell carcinoma (SCC-25) cells, six-well plates seeded with SCC-25 cells were exposed to different concentrations of fulvic acid for 72 hours. The cytotoxicity and cell proliferation were measured. It was determined that fulvic acid inhibits the growth of SCC-25 cells at concentrations of fulvic acid above 2% (volume %). The suppressive mechanisms observed by fulvic acid on both S. mutans and SCC-25 cells could improve overall oral health.
Link: https://scholarworks.iupui.edu/handle/1805/5369
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Conclusion: Fulvic acid can kill human breast cancer cells.
Title: A New Insight Into the Anti Proliferative and Apoptotic Effects of Fulvic and Humic Acids as Bio Product of Humus on Breast Cancer Cells, Optimized by Response Surface Methodology
Type of Document: Peer-reviewed journal article
Takeaway: Our results showed that humic acid (HA) and fulvic acid (FA) induced apoptosis, reduced cell viability and gene expression in the cured MCF7 (human breast cancer) cells.
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Conclusion: Fulvic acid compositions absorbed through the skin may help treat cancer.
Title: Special preparation for the treatment of cancer recovery through medicinal mineral spring baths.
Document Type: Patent
Conclusion: The present invention relates to a special preparation for mineral spring medicinal bath for treating cancer, and the mineral spring medicinal bath is a combination of traditional mineral spring treatment and fumigation and washing treatment of traditional Chinese medicine. The essential trace elements for cancer patient and the Chinese medicine decoction with the function of resisting cancer and strengthening resistance are put into the bathtub and kept at a temperature above 34 degrees Celsius for the patient to absorb and his skin to absorb the effective components to accelerate the recovery of cancer. The method of treating internal diseases from outside is suitable for treating various cancers of lung, stomach, liver, kidney, large intestine, uterus, etc. and is safe, stable and convenient. It can be combined with drug therapy, radiotherapy and chemotherapy to increase the treatment effect and reduce toxic side effects. The chemical content of this bath is selenium (sodium selenite), molybdenum (sodium molybdate), germanium (fulvic acid), zinc (zinc sulfate), silicon (sodium silicate), iodine (sodium iodide), iron (ferrous sulfate), manganese (potassium permanganate).
Link: https://patents.google.com/patent/CN1531937A/
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Conclusion: Fulvic acid derivatives may have anticancer properties.
Title: Anti-aging drug and anti-cancer health protection articles preparation facilities.
Document Type: Patent
Conclusion: The patent describes a high purity active ingredient mixture comprising xanthohumol, mannan, selenium malt seedlings, house mushroom, oleander blue tea and mulberry huang for anti-aging, anti-muscle atrophy and anti-cancer activities. In the preparation step, fulvic acid, fructus hordei germinatus and brewer's yeast are sent to a biological extraction reactor through a smart feeder to produce xanthohumol (fulvic acid is 30-99%:1-70% relative to the mixture ratio of fructus hordei germinatus and brewer's yeast).
Link: https://patents.google.com/patent/CN204949483U/
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Conclusion: Fulvic acid compositions can treat cancer.
Title: Solid pharmaceutical compositions and processes for their production.
Document Type: Patent
Conclusion: The present invention relates to a novel solid pharmaceutical composition containing 1% (w/w) sodium fulvic acid together with other components, and a method for mass producing it. The invention also provides a method for treating cancer using said pharmaceutical compositions.
Link: https://patents.google.com/patent/TWI597073B/
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Conclusion: Formulations containing fulvic acid may have anticancer properties.
Title: Nutritional supplement composition for treating coronavirus infections, cancer, ME, post viral & Chronic fatigue syndrome & neurodegeneration in an individual
Document Type: Patent
Takeaway: A chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising NMN, NAD , PQQ, CoQ10, piperine, vitamin B7, vitamin B9, and vitamin B12. Further disclosed is a chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising Resveratol, Pterostilbene, Quercetin, Baikal Skullcap, L-Theanine, Curcuminoids (Turmeric Extract), Lion's Mane Mushrooms, vitamin B1, vitamin B2, vitamin B5, vitamin B6, Piperine and Zinc Complex. Further disclosed is chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising Alpha Lipoic Acid (ALA), Acetyl-L-Carnitine (ALCAR), N-Acetyl Cysteine (NAC), Ginkgo Biloba, Beta Glucans, Epigallocatechin 3-Gallate (EGCG), Green Tea Extract, Pomegranate Extract (incl. Ellagic Acid), Olive Leaf Extract (incl. Oleuropein and Hydroxytyrosol), Green Coffee Bean Extract (incl. Chlorogenic Acids), Theacrine, piperine, and additionally, humic and fulvic acids in some embodiments.
Link: https://patents.google.com/patent/GB2596849A
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Conclusion: Formulations containing fulvic acid may have anticancer properties.
Title: Compositions and methods for treating cell proliferation disorders.
Document Type: Patent
Conclusion: This patent describes a method of treating a person suffering from a cell proliferative disorder (including cancer and some autoimmune disorders) characterized by increased recruitment of voltage-gated ion channels, comprising: administering to the person a composition composed of a compound selected from the group consisting of matrine, oxymatrine, artemisinin, agmatine, and vinpocetine. The method may further comprise co-administration of an enhancer compound selected from the group consisting of hydroxycitric acid, a sodium or potassium salt of hydroxycitric acid, fumaric acid, an ester of fumaric acid, fulvic acid, and a salt of fulvic acid.
Link: https://patents.google.com/patent/WO2005044272A1/
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Conclusion: Humic substances have anticancer activity for Leukemia.
Title: Antitumor effect of humus extract in transplantable murine leukemia L1210
Document Type: Peer-Reviewed Journal Article
Conclusion: Humic substances are formed during the decomposition of organic matter in humus found in many natural environments where organic materials and microorganisms have been present. In the present study, humus extract showed an antitumor effect on L1210 tumor development in isogenic DBA/2 mice with a delay in tumor formation and a significantly smaller tumor mass inferring a significant increase in lifespan of the mice. The antitumor effect was not due to direct killing of L1210 or induction of apoptosis in tumor cells by humus extract.
