COVID19, SARS & Influenza Studies
Conclusion: Humic substances can activate the immune system to inhibit COVID-19
Title: Humic substances as environmentally friendly organic waste potentially help as a natural antivirus to inhibit COVID-19
Document Type: Peer-Reviewed Journal Article
Conclusion: The information gathered in this review indicates that HS may act as an immune modulator, influence redox status, and potentially affect gut health. HS has been shown to decrease pro-inflammatory markers but also activate the immune system to inhibit COVID-19. It has been shown to reduce oxidative stress and even induce apoptosis in liver cancer lines. HS has also been shown to influence the microbiome and possibly improve gut function. This will help to make conclusive statements about the function of HS and its influence on immune-related diseases.
Link: http://dx.doi.org/10.47587/SA.2020.1202
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Conclusion: Humic substance mixtures containing fulvic acid may possess virus-killing activity against SARS-CoV-2 (coronavirus).
Title: Polyelectrolyte Nanodispersions Based on Humic Substances: Isolation, Physicochemical Characterization and Evaluation of Biological Activity
Document Type: Peer-Reviewed Journal Article
Takeaway: The results of our research suggest that the chemical structure of natural humus polyelectrolytes is due to the stabilizing interaction of macromolecules with nanoparticles of lyophobic sols–metals with the formation of complexes of the macromolecule-nanoparticle type. The intensity of the fluorescence signal showed that in addition to the organic structure of the non-stoichiometric composition and irregular heterogeneous structure with numerous functional groups, occluded metal nanoparticles are present in the components of humic acids. Polyelectrolytes modified in this way are a unique transport object for medicinal substances. In addition, our studies have demonstrated the possibility of independent binding of naturally branched polyelectrolyte complexes of humic substances with SARS-CoV-2 S-protein in vitro. A study of the EHS effect on the SARS-CoV-2 virus infectious titer in the Vero E6 cell showed the effective against viruses both in the virucidal scheme (the SI is 11.90–22.43) and treatment/prevention scheme (the SI is 34.85– 57.33). We assume that the proposed approach will be useful in laboratory and clinical settings for the development of standard quality control protocols, as well as the creation of a promising standardized drug with virucidal treatments for the prevention of coronavirus infection.
Link: https://www.mdpi.com/1999-4923/13/11/1954/htm
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Conclusion: The antiviral and immune-stimulating activities of fulvic acid may make it effective against SARS-CoV-2 (coronavirus).
Title: Prevention of viral effect and enhancement of immune system with the help of Himalayan herbal plants and raw medicines in patients with SAR-COV-2; A review
Document Type: Review Article
Conclusion: Fulvic acid, humic acid, hippuric acid and benzopyrones have immunostimulant and antiviral activity, which may be their possible mechanism of action against SARS-CoV-2.
Link: https://dergipark.org.tr/en/pub/cupmap/issue/62212/948975
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Conclusion: Fulvic acid-containing compositions may be effective against COVID-19.
Title: THE PANDEMIC- COVID 19- A RACE OF PHARMACEUTICALS
Type of Document: Review article
Takeaway: Compositions with fulvic acid, humic acid, hippuric acid, and benzopyrones have been used against COVID-19 as a natural treatment strategy.
Link: http://plantarchives.org/SPECIAL%20ISSUE%2021-1/346%20(2098-2104).pdf
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Conclusion: Fulvic acid could have potential as a drug against COVID-19.
Title: Interaction of Drug Candidates with Various SARS-CoV-2 Receptors: An in Silico Study to Combat COVID-19
Document Type: Peer-Reviewed Journal Article
Conclusion: In this work, molecular docking was used to study (in silico) the interaction of 24 ligands, divided into four groups, with four SARS-CoV-2 receptors, the Nsp9 replicase, the main protease (Mpro), the endoribonuclease NSP15 and the spike protein (S protein) that interacts with human ACE2. The results showed that the antimalarial drug Metaquine and the anti-HIV antiretroviral Saquinavir interacted with all the receptors studied, indicating that they are potential candidates for multi-target drugs. for COVID-19. Fulvic acid also showed a binding energy equal to −7 kcal/mol with receptors 2 and 4, two of the SARS-CoV-2 receptors.
Link: https://pubs.acs.org/doi/full/10.1021/acs.jproteome.0c00327
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Conclusion: Fulvic acid may be a potential inhibitor of SARS-CoV-2 (coronavirus).
Title: Structure-function characteristics of SARS-CoV-2 proteases and their potential inhibitors from microbial sources
Document Type: Review Article
Conclusion: SARS-CoV-2 viral proteases, 3-chymotrypsin-like protease (3CLpro) and papain-like cysteine protease (PLpro), have emerged as a promising target to study due to their essential roles in virus propagation via RNA transcription, translation, protein synthesis, processing and modification, virus replication, and host infection. Therefore, we have collected various published literature in detail on the structures, functions of SARS-CoV-2 proteases, and potential inhibitors from microbial sources as a help for other researchers working on COVID-19. Fulvic acid is also a potential inhibitor from microbial sources of SARS-CoV-2 proteases.
Link: https://www.mdpi.com/2076-2607/9/12/2481/pdf?version=1638276907
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Conclusion: Fulvic acid has an antiviral effect against COVID-19-causing SARS-CoV-2 virus.
Title: A Comprehensive Biological and Physico-Chemical Characterization of Humic and Fulvic Acids Nanoparticles as a Perspective Drug
Type of Document: Journal article
Conclusion: The results of the study of the antiviral activity of extracted humic substances (EHS) and fulvic acid (FA) showed that the study objects in the culture of Vero-E6 cells, at non-toxic doses for the cells, suppress the reproduction of the SARS-CoV-2 virus both in the study of the virucidal effect and in the study of the antiviral activity according to the therapeutic and prophylactic injection model scheme. The results obtained suggest that standardized drugs based on humic acids may open new perspectives in their biomedical application as antiviral drugs.
Link: https://www.preprints.org/manuscript/202106.0245/v1
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Conclusion: Formulations containing fulvic acid may be effective in the treatment of COVID-19.
Title: Composition of nutritional supplement for the treatment of coronavirus infections, cancer, MS, chronic and post-viral fatigue syndrome and neurodegeneration in an individual
Document Type: Patent
Conclusion: The present invention discloses a chemopreventive and cytotoxic formulation or composition that is effective in treating coronavirus and other infections, cancer, PVLS/M1E/CES, fibromyalgia, enhances immune, mitochondrial, stem cell and brain function, and reverses epigenetic aging in an individual. In one embodiment, the composition further comprises Shilajit (mineral pitch containing humic and fulvic acids). In one embodiment, the composition further comprises Shilajit (mineral pitch containing humic and fulvic acids) in an amount of about 25 mg to 250 mg. In one embodiment, the composition further comprises Shilajit (mineral pitch containing humic and fulvic acids) in an amount of about 100 mg.
Link: https://patents.google.com/patent/GB2596849A/
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Conclusion: Fulvic acid-supplemented intranasal iodine drops may be effective in inactivating SARS-CoV-2 virus (coronavirus) and preventing its transmission.
Title: In vitro efficacy of “essential iodine drops” against severe acute respiratory syndrome-Coronavirus 2 (SARS-CoV-2)
Document Type: Journal Article
Conclusion: This study evaluated the virucidal activity of aqueous solution of iodine-V (a clathrate complex formed by elemental iodine and fulvic acid) as essential iodine drops (EID) containing 200 μg elemental iodine/mL against SARS-CoV-2 to determine whether it is a better alternative to PVP-I. The substantial reductions in log reduction value (LRV) by iodine-V in EID confirmed the activity of EID against SARS-CoV-2 in vitro, demonstrating that iodine-V in EID is effective in inactivating the virus in vitro and therefore suggesting its potential application via the intranasal route to reduce SARS-CoV-2 transmission from known or suspected COVID-19 patients.
Link: https://www.biorxiv.org/content/10.1101/2020.11.07.370726v1.abstract
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Conclusion: Natural formulations containing fulvic acid may be effective in the treatment of COVID-19.
Title: Protection against coronavirus infection using extracts and extract components.
Document Type: Patent
Conclusion: This invention relates to methods for treating, preventing and protecting against viral infections, including coronavirus infection such as COVID-19, with natural extracts and/or their components. The methods include administering plant and/or herbomineral extracts such as extracts of Shilajit, Withania somnifera, Asparagus racemosus, Terminaha chebula, Terminaha bellirica, Phyllanthus emblica, Azadirachta indica, and/or a trivalent chromium complex with extracts of P. emblica and shilajit; and also administering components of the extract such as 3,8-dihydroxy-6H-benzo[c]chromen-6-one and 3-hydroxy-6H-benzo[c]chromen-6-one. In one embodiment, a Shilajit composition of this invention contains not less than 50% w/w DBP core fulvic acids and not less than 10.3% w/w combined dibenzo-α-pyrones and free dibenzo-α-pyrones (DCP) chromoproteins. Dibenzo-α-pyrones are also known as urolithins, for example urolithin A and urolithin B. In one embodiment, PrimaVie® as a composition of this invention is a standardized aqueous extract containing 56-63% dibenzopyrone core fulvic acids and 12-18% free dibenzo-α-pyrones and combined chromoprotein-conjugated dibenzo-α-pyrones.
Link: https://patents.google.com/patent/US20220054575A1
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Conclusion: Formulations containing fulvic acid may be effective in preventing the cytokine storm that occurs in COVID-19.
Title: Reduction of cytokine storm and pathological inflammation, including that caused by coronavirus, using sphagnum and its extracts.
Document Type: Patent
Conclusion: In some embodiments, the methods and compositions encompassed herein are used to treat viral infections, including coronavirus infections (such as SARS-CoV-2), or symptoms associated with such infections. Certain embodiments comprise methods and compositions for preventing lung injury of any type in an individual. The disclosure encompasses methods and compositions for stimulating the production of one or more growth factors, including keratinocyte growth factor (KGF), in an individual. In some embodiments, the issue of cytokine storm, as well as lung protection against cytokine storm, is addressed through the use of humic acid, fulvic acid, and/or various Sphagnum components.
