Immune system studies

Immunomodulatory Properties of Fulvic and Humic Acid

Fulvic and humic acids have a significant impact on the immune system, helping to regulate and strengthen both cellular and humoral immunity. Below are various research findings that highlight their potential as natural immunomodulators and their ability to fight infections, reduce inflammation, and improve overall health.

Major Discoveries on Fulvic and Humic Acid

1. Synergistic Effects on the Immune System

Conclusion: Humic acids, alone or in combination with yeast-derived glucan, stimulate both cellular and humoral immune responses, showing their efficacy as active immunomodulators.
Reference: Glucan and humic acid: synergistic effects on the immune system .
Link: Sci -Hub .

2. Reduction of Allergic Reactions

Conclusion: Fulvic acid decreases the activity of allergy-related immune cells, such as the expression of genes involved in immune responses and the release of chemical mediators.
Reference: Microarray analysis of immediate-type allergy in KU812 cells in response to fulvic acid .
Link: Sci -Hub .

3. Reduction of Inflammation by Human Monocytes

Conclusion: Fulvic acid inhibits the expression of inflammatory mediators such as COX-2 and PGE2, modulating key inflammatory pathways.
Reference: Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes .
Link: NCBI .

4. Stimulation of Proinflammatory Cytokines

Conclusion: Humic acid significantly increases the production of key cytokines such as IL-12, TNFα and IFNγ, strengthening the immune response against pathogens.
Reference: Immunomodulatory properties of humic acids extracted from oligotrophic peat of Sphagnum magellanicum .
Link: Sci -Hub .

5. Activation of Human Macrophages

Conclusion: Humic acids have a concentration-dependent bimodal effect, showing pro-inflammatory activity at low doses and anti-inflammatory activity at high doses.
Reference: Bimodal effect of humic acids on TNF-α release from differentiated U937 cells .
Link: Sci -Hub .

6. Benefits of Drinks with Fulvic Acid

Conclusion: Beverages containing fulvic acid improve immunity, prevent gastrointestinal diseases, regulate blood glucose and lipids, and promote better appetite and sleep.
Reference: Health care drink composed of natural fulvic acid .
Link: Google Patents .

7. Immunity and Human Neutrophils

Conclusion: Humic substances activate latent neutrophils, converting them into defensive cells activated against infections.
Reference: Humate-induced activation of human granulocytes .
Link: Sci -Hub .

8. Stimulation of Macrophages and Lymphocytes

Conclusion: Humic and fulvic acids stimulate macrophages and lymphocytes, improving the body's ability to fight infections.
Reference: Characterization and Biological Activities of Humic Substances from Mumie .
Link: Sci -Hub .

General Conclusion

Humic and fulvic acids represent exceptional natural tools for enhancing immunity. Their ability to regulate inflammation, stimulate cytokine production, and activate immune cells positions them as key allies in the prevention and treatment of infections, allergies, and inflammatory conditions. 🌿

For more information, explore the studies and patents mentioned in this collection.