Immune system studies
Conclusion: Humic acids can stimulate the immune system in several ways.
Title: Glucan and humic acid: synergistic effects on the immune system
Document Type: Peer-Reviewed Journal Article
Conclusion: We decided to evaluate the immunological effects of two different types of humic acids, which differ in their source and biochemical characteristics. Using both components alone or in combination with the well-established yeast-derived immunomodulatory glucan, we measured their effects on both the cellular (phagocytosis and tumor suppression) and humoral (antibody production and cytokine secretion) branches of immune reactions. In summary, our results suggest that humic acids are biologically active immunomodulators.
affecting both the humoral and cellular branches of immune reactions. In addition, the two humic acids studied
Here we are working in synergy in the stimulation of the immune reaction, supporting future studies of these natural immunomodulators.
Link: https://sci-hub.hkvisa.net/10.1089/jmf.2009.0178
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Conclusion: Fulvic acid reduces the activity of human immune cells involved in causing allergy.
Title: Microarray analysis of immediate-type allergy in KU812 cells in response to fulvic acid
Document Type: Peer-Reviewed Journal Article
Conclusion: Fulvic acid extracted from excess solubilized sludge (SS-FA) affected the expression of human genes that were involved in the following pathways: signal transduction, interaction between cytokines and cytokine receptors, immune response, cell adhesion molecules, and IgE receptor β-subunit response.
Link: https://sci-hub.se/https://pubmed.ncbi.nlm.nih.gov/21331654/
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Conclusion: Fulvic acid reduces inflammation caused by the stimulation of human immune cells called monocytes.
Title: Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes
Document Type: Peer-Reviewed Journal Article
Conclusion: In conclusion, fulvic acid (FA) inhibited COX-2 expression and PGE2 production from homocysteine-induced monocytes. Homocysteine stimulation in monocytes resulted in increased phosphorylation of ERK and JNK and activation of NF-κB. FA inhibited homocysteine-induced inflammatory mediator expression by regulating the activation of these pathways.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369892/
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Conclusion: Humic acid stimulated the germ-killing immune response of human immune cells called mononuclear cells.
Title: Immunomodulatory properties of humic acids extracted from oligotrophic peat of Sphagnum magellanicum
Document Type: Peer-Reviewed Journal Article
Conclusion: The humic acid (HA) sample studied stimulates the production of proinflammatory cytokines IL-12,
TNFα, IL-1β and IFNγ by human mononuclear cells. In human peripheral blood mononuclear cells, it was shown that the HA sample studied also significantly enhanced the secretion of the main cytokines typical of Th1-type polarization of the immune response, which acts against pathogen invasion. The production of IL-12 increased 8.3-fold, TNFα 93.6-fold, IFNγ 170-fold compared to the control.
Link: https://sci-hub.se/https://link.springer.com/article/10.1007/s10517-021-05088-5
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Conclusion: Humic acid has immunomodulatory effects on human immune cells called macrophages.
LPS-induced Title: Bimodal effect of humic acids on TNF-α release from differentiated U937 cells
Document Type: Peer-Reviewed Journal Article
Conclusion: The results demonstrate a concentration-dependent bimodal effect of humic acid (HA) on TNF-alpha release from LPS-stimulated differentiated U937 cells (which are human macrophage-like cells) for both the natural black peat HA from the Altteich bog and the HA-like polymer KOP. Low concentrations of HA (10–80 microg/ml) enhanced TNF-alpha release by up to three-fold (pro-inflammatory activity), whereas HA concentrations >100 microg/ml reduced it by approximately 10-fold (anti-inflammatory activity). Fulvic acid (FA) failed to enhance TNF-alpha release but reduced it by half at higher concentrations (>200 microg/ml). Brown water HA had no significant effect on TNF-a release.
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Conclusion: Beverages containing fulvic acid promote health by preventing and treating gastrointestinal diseases, preventing tumors, improving human body immunity, reducing blood glucose and fat, improving appetite and sleep.
Title: Health care drink composed of natural fulvic acid, as well as its preparation method.
Document Type: Patent
Conclusion: The invention describes a health care beverage composed of natural fulvic acid, as well as a method of preparing the same. The health care composite beverage is prepared by mixing one or more of natural fulvic acid of edible grade, traditional Chinese medicine extracts, a sweetening agent, an acidulant or a stabilizer with water. The beverage comprises the following components in weight percentage: 0.1-0.6% of natural fulvic acid of edible grade, 0.05-0.2% of traditional Chinese medicine extracts, 2-6% of the sweetening agent, 0.01-0.5% of the acidulant, 0.01-0.15% of the stabilizer and the balance being water. The beverage described by the invention is abundant in raw material and simple in its preparation method. The medical functions of natural fulvic acid are applied to daily beverages, so that the beverage has coffee luster, unique flavor, pleasant taste in sweetness and sourness and is free of medicine flavor, preservatives or pigments. The beverage has health care functions of preventing and treating gastrointestinal diseases, preventing tumors, enhancing human body immunity, lowering blood glucose and fat, improving appetite and sleep and the like and is free of side effects when drunk for a long time, so that the beverage is an ideal health care beverage.
Link: https://patents.google.com/patent/CN103564587B/en?q=fulvic+acid&oq=fulvic+acid&page=4
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Conclusion: Fulvic acid may help reduce the side effects of alcohol consumption.
Title: Fulvic acid medical device with sobering and anti-drunkenness function
Document Type: Patent
Conclusion: The invention provides a fulvic acid health care product with a function of improving sobriety and anti-drinking. The health care product is an oral liquid characterized by comprising the following components in weight percentage: 1-10 percent fulvic acid, 5-30 percent sugar, and the balance water. The invention obviously accelerates the metabolism of alcohol in human blood, increases the tolerance of human body to alcohol, shortens the time of drunkenness, and has a favorable function of sobering up and anti-drinking. The fulvic acid health care product is a safe and reliable natural product and can meet people's needs.
Link: https://patents.google.com/patent/CN101721425A/en?q=fulvic+acid+health&oq=fulvic+acid+health
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Conclusion: The composition containing fulvic acid reduces hair loss and promotes hair growth.
Title: Composition for preventing hair loss and method of preparing it.
Document Type: Patent
Conclusion: The present invention is a composition relating to hair loss prevention and a hair growth promoting composition using natural materials. Namely, the present invention is an active ingredient, ovine, bovine, goat colostrum, beta glucan extracted from yeast (Beta Glucan), peat moss extracted from fulvic acid (Fulvic Acid), Amazon fruit, caffeine, guarana extracted from guarana and eucalyptus tree extract are the main ingredients and are composed of colostrum and beta glucan as the main ingredients. The composition consists of a scalp coating agent consisting of natural acid and caffeine and eucalyptus extract as the main component, and is related to a hair loss preventing and hair growth promoting composition that can achieve a more effective hair loss preventing and hair growth promoting effect by using them in parallel.
Link: https://patents.google.com/patent/KR101274583B1/en?q=fulvic+acid+health&oq=fulvic+acid+health&page=9
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Conclusion: Shilajit can strengthen the immune system.
Title: Mast cell protective effects of shilajit and its components
Document Type: Peer-Reviewed Journal Article
Conclusion: Shilajit (100 ug/mL) and a combination of its components MCB, DDP and fulvic acids significantly protected rat mesenteric mast cells against antigen-induced degranulation.
Link: https://sci-hub.hkvisa.net/10.1002/ptr.2650030606
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Conclusion: Fulvic acid promotes hair growth.
Title: Compositions and methods for human use containing fulvic acid.
Document Type: Patent
Conclusion: The present invention provides compositions comprising fulvic acid. The present invention further provides methods and compositions for promoting hair growth involving the use of fulvic acid.
Link: https://patents.google.com/patent/US20070212434A1/en?q=fulvic+acid&oq=fulvic+acid
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Conclusion: Oxyfulvic acid inhibits the inflammatory response of the human immune system to allergens.
Title: Pilot study to evaluate the safety and therapeutic efficacy of topical oxyfulvic acid in atopic volunteers
Document Type: Peer-Reviewed Journal Article
Conclusion: In this double-blind crossover study, 23 healthy volunteers allergic to grass or house dust mite allergen were recruited. Volunteers were randomly assigned to placebo, 1% hydrocortisone, 4.5% or 9% oxyfulvic acid.
Creams. Creams were applied under occlusion 1 h before intradermal allergen challenge and then every 8 h for 3 days (21-day intervals). Topically applied oxyfulvic acid had no significant effect on any of the safety parameters and also did not induce sensitization when applied to the skin. Oxyfulvic acid (4.5%) caused inhibition of the inflammatory reaction elicited at 15 min. These changes were similar to those caused by hydrocortisone.
Link: https://sci-hub.se/10.1002/ddr.10116
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Conclusion: Fulvic acid prevents allergy symptoms triggered by human immune cells.
Title: Inhibitory effect of fulvic acid extracted from Canadian sphagnum peat on the release of chemical mediators by RBL-2H3 and KU812 cells
Document Type: Peer-Reviewed Journal Article
Conclusion: Fulvic acid (FA) was extracted and purified from Canadian Sphagnum peat moss (CP-FA) and also inhibited histamine release from KU812 cells stimulated by A23187 plus PMA or compound 48/80.
Link: https://sci-hub.se/https://pubmed.ncbi.nlm.nih.gov/17485833/
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Conclusion: Fulvic acid stimulates the immune system to help defend the body from infections.
Title: Fulvic Acid: A Natural and Multifaceted Approach to the Treatment of Inflammatory Dermatosis
Document Type: Review Article
Conclusion: Fulvic acid stimulates the immune system to help defend the body from infections.
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Conclusion: Humic acids strengthen the immune system.
Title: Study of the influence of humic acid macromolecules on the structure of erythrocytes of some animals by the absorption method
Document Type: Peer-Reviewed Journal Articles
Conclusion: Recently, there has been an increase in interest in the application of humic acids (HA) in medicine. These are examples of the effect of HA on some vitally important properties of the human organism. One of the most pronounced effects of HA is the strengthening of the general immune response. Humic compounds regulate the amount of glycoproteins that affect the balance of T and B lymphocytes. In addition, they activate the synthesis of interleukins 1 and 2 and the production of endogenous interferon and gamma globulins that activate depressed functions of the immune system.
Link: https://www.intechopen.com/chapters/66666
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Conclusion: Fulvic acid exerts an activating effect on the immune system.
Title: Characterization and Biological Activities of Humic Substances from Mumie
Document Type: Peer-Reviewed Journal Article
Conclusion: The results of our studies suggest that the activating effect of mumie on the immune system is caused in part by fulvic acid (FA) stimulation of macrophages and lymphocytes.
Link: https://sci-hub.se/10.1021/jf021101e
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Conclusion: Humic substances can activate infection-fighting cells of the human immune system called neutrophils.
Title: Humate-induced activation of human granulocytes
Document Type: Peer-Reviewed Journal Article
Conclusion: The results suggest that low molecular weight humic substances originating from decaying organic material contain chemical structures that may act as signals to convert dormant human neutrophils into activated cells.
Link: https://sci-hub.se/https://link.springer.com/article/10.1007/BF02899524
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Conclusion: Natural humic acids can improve immunity.
Title: Effects of humic acids in vitro
Document Type: Peer-Reviewed Journal Article
Conclusion: The results of the in vitro study performed with naturally sourced humic acids showed the potential of these substances as promising immunity-enhancing agents.
Link: https://sci-hub.ru/https://pubmed.ncbi.nlm.nih.gov/21487922/
